Joining CMOS technology with biology
BioCMOS offers bioanalytical instruments miniaturized on CMOS LSI to detect various biophenomena or to actuate biosystems. These BioCMOS systems utilize the CMOS LSI to facilitate faster, repeatable, portable, and standardized biological experiments at low cost with a small volume of biological sample.
CMOS: Complementary Metal-Oxide-Semiconductor
transistors
LSI: Large Scale Integrated circuit
16x16 Biosensor Array test chip
DNA chips are playing important roles in molecular biology, pharmaceutical research, and clinical applications. Semiconductor field effect transistors have attracted attention for label-free electrical detection of biomolecular interactions. Fully electrical detection using CMOS LSIs has many advantages on easy-handling, miniaturization, mass-production, system integration, and standardization.
K. Nakazato, M. Ohura, H. Ozawa, and S. Uno, "A BioCMOS LSI circuit with extended-gate FET sensor array," to be presented at 2008 ISSDM, E6-3, Sept. 25, 2008, Tsukuba, Japan, abstract pdf (297KB) , presentation pdf (2.1MB)
K. Nakazato, M. Ohura, and S. Uno, "CMOS cascode source-drain follower for monolithically integrated biosensor array," IEICE Trans., E91-C, No.9, pp.1505-1515, Sept. 2008. pdf(1.6MB)
K. Nakazato, M. Ohura, and S. Uno, "Source-drain follower for monolithically integrated sensor array", Electron. Lett., vol. 43, no. 23, pp.1255-1257, November 2007
K. Nakazato, M. Ohura, K. Sugimoto, J. Tsukada, and S. Uno, "Extended-gate MOSFET Biosensor Array LSIs", Fourth International Conference on Molecular Electronics and Bioelectronics (M&BE4), Tokyo, Japan, 14-16 March (2007) pdf (744KB)
M. Ohura, S. Uno, and K. Nakazato, "An Analog BioCMOS LSI Circuit for the Electrical Detection of Biomolecular Charges with Extended Gate MOSFET Cells," 2006 IEEJ International Analog VLSI Workshop, P06008, pp. 1-6, November 16-18, 2006, Hangzhou, China pdf (472KB)
contact : mail@biocmos.com
Professor Kazuo
Nakazato
Department of Electrical Engineering and Computer
Science,
Graduate School of Engineering, Nagoya University,
Furo-cho,
Chikusa-ku, Nagoya 464-8603, Japan
FAX: 81-52-789-3139
http://www.nuee.nagoya-u.ac.jp/labs/nakazatolab/