Biosensor Integrated Circuit

In view of the growing concerns about such issues as food security, health care, evidence-based care, infectious disease, and tailor-made medicine, a portable gene-based point-of-care testing (POCT) system is needed. For a system that anyone can operate anywhere and obtain immediate results, a new biosensor chip must be developed. Electrical detection using complementary metal-oxide semiconductor (CMOS) integrated circuits has great potential since it eliminates the labeling process, achieves high accuracy and real-time detection, and offers the important advantages of low-cost, compact equipment.

Biosensors are devices that combine a biological component (a recognition part) and a physicochemical detector component (a transducer). The recognition part can be constructed using enzymes, antibodies, cells, tissues, nucleic acids, and peptide nucleic acids. The transducer consists of potentiometric, amperometric, and impedimetric sensor circuits. A few biological molecules can be detected in a micrometer-scale region. Sample with milli liter is divided into pico liters, and detected in massively-parallel. We have developed such biomedical chips with high integration of micrometer-scale sensors. We have also developed stand-alone equipment. BCT-II is a general purpose equipment, suitable to research and development. BCT-III is a user friendly equipment specialized to specific application. BCT-II and BCT-III use same chips, so it is east to move from research and development to products.